Many people suffering from arthritis, especially rheumatoid arthritis, are now opting for detoxification programs to treat their arthritis. Detoxification (detox for short) programs have proved especially effective in treating rheumatoid arthritis.
Rheumatoid arthritis is an auto-immune disease where the body's immune system mistakes one's own body tissues as invaders. Actually, the body's immune system turns against the body primarily due to toxins that get accumulated over a period in time.
Detoxification programs for arthritis work by facilitating detoxification and cleansing of bowels, kidneys, lungs, liver and the blood. Toxic wastes accumulate in our bodies because of various reasons, such breathing in polluted air, smoking, or may be because of improper dietary habits. These toxic wastes cause hormonal imbalance, impaired immune function, nutritional deficiencies and inefficient metabolism.
Because of such complications, a person suffering from arthritis experiences his disease conditions getting worse. The detoxification programs for arthritis target these toxic waste elements present in the body and help the body to eliminate them.
How do the Detoxification programs work?
The detoxification programs for arthritis work by providing anti-oxidants, vitamins, minerals and other nutrients to the body and by enabling the digestive system and excretory system to eliminate toxins released by the body during metabolism.
Detoxification programs speed up the growth of new cells, which eventually promotes healing. A patient then feels renewed energy surging through his body, starts having clearer thoughts leading to enhanced mental processes and has an overhauled body system.
Our Balance Holistic Products have a tailor-made Detox Programme for Rheumatoid Arthritis, and all products are 100% natural with no added chemicals.
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A healthy intestinal microbiome is essential to optimal wellness, and knowledge surrounding this relationship has grown substantially in recent years. The connection between gut health and rheumatoid arthritis (RA) development is one example, as the gut microbiota has been proposed to be an important environmental factor of the disease.1 RA is one of several conditions where gut permeability predates symptoms, and it may be possible to prevent joint damage by treating the gut. What is the state of research on arthritis, the microbiome, and gut permeability?
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Inflammatory biomarkers are known to emerge years before a definitive diagnosis of rheumatoid arthritis is possible.2 One theory dating back to the beginning of the 20th century suggested that RA emerges from mucosal tissues and dysbiosis, and only later do problems occur in the synovial fluid and joints.3,4 More recent research supports this chain of events. For example, research suggests that IgA antibodies, which are closely associated with mucosa, are elevated in preclinical and recently diagnosed RA patients.5 Studies continue to evaluate the relationship between RA risk and inflammatory indicators, including antibodies, cytokines, and proteins such as serum amyloid A (SAA).6-8
People with RA have different gut microbial populations than people with other inflammatory diagnoses3—in particular, individuals newly diagnosed with RA have been found to have reduced levels of Faecalibacterium in the gut, a butyrate-generating beneficial bacterium.9 A small 2019 study found significant differences in the microbial distribution of various taxa from phylum to genus levels between 25 healthy subjects and 29 early RA patients.10 Phylum Bacteroidetes was enriched in early RA patients, while Actinobacteria, including the genus Collinsella, was enriched in healthy subjects.
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Functional analysis based on clusters of orthologous groups revealed that the genes related to the biosynthesis of menaquinone, known to be derived from gram-positive bacteria, were enriched in healthy subjects, while iron transport–related genes were enriched in early RA patients. Genes related to the biosynthesis of lipopolysaccharide, the gram-negative bacterial endotoxin, were enriched in clinically apparent RA patients.10More recently, researchers in Japan performed a whole gut virome analysis based on the shotgun sequencing of 476 individuals with RA, systemic lupus erythematosus (SLE), multiple sclerosis (MS), and healthy controls.11 The case-control comparison revealed that crAss-like phages, which are one of the main components of a healthy gut virome, significantly decreased in the gut of the patients with autoimmune diseases, specifically the patients with RA and SLE. Multiple bacterial targets of crAss-like phages were identified (e.g., Ruminococcus spp).11 Higher levels of gingival disease and unhealthy oral microbiota are also associated with the early stage of RA.9 Taken together, these factors suggest that risk of RA development may be reduced for some patients if the signs are recognized early enough and gut health is restored.
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References
1. Maeda Y, Takeda K. Host–microbiota interactions in rheumatoid arthritis. Exp Mol Med.2019;51(12):1-6. doi:1038/s12276-
019-0283-6
2. Ramos-Remus C, Castillo-Ortiz JD, Aguilar-Lozano L, et al. Autoantibodies in prediction of the development of rheumatoid
arthritis among healthy relatives of patients with the disease. Arthritis Rheumatol. 2015;67(11):2837-2844.
doi:1002/art.39297
3. Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020;110:102400.
doi:1016/j.jaut.2019.102400
4. Manasson J, Blank RB, Scher JU. The microbiome in rheumatology: where are we and where should we go? Ann Rheum
Dis. 2020;79(6):727-733. doi:1136/annrheumdis-2019-216631
5. Derksen VFAM, Allaart CF, Van der Helm-Van Mil AHM, Huizinga TWJ, Toes REM, van der Woude D. In rheumatoid arthritis
patients, total IgA1 and IgA2 levels are elevated: implications for the mucosal origin hypothesis. Rheumatology (Oxford).
2022;62(1):407-416. doi:1093/rheumatology/keac237
6. Meng S, Jing L, Zhang W, Wang F, Dong Y, Dong D. Research progress on serological indices and their clinical application
in rheumatoid arthritis. J Clin Lab Anal. 2022;36(9):e24576. doi:1002/jcla.24576
7. Zhou J, Dai Y, Lin Y, Chen K. Association between serum amyloid A and rheumatoid arthritis: a systematic review and
meta-analysis. Semin Arthritis Rheum. 2022;52:151943. doi:1016/j.semarthrit.2021.12.011
8. Abdelhafiz D, Baker T, Glascow DA, Abdelhafiz A. Biomarkers for the diagnosis and treatment of rheumatoid arthritis – a
systematic review. Postgrad Med. 2023;135(3):214-223. doi:1080/00325481.2022.2052626
9. Chu XJ, Cao NW, Zhou HY, et al. The oral and gut microbiome in rheumatoid arthritis patients: a systematic review. Rheumatology (Oxford). 2021:60(3):1054-
1066. doi:1093/rheumatology/keaa835
10. Jeong Y, Kim JW, You HJ, et al. Gut microbial composition and function are altered in patients with early rheumatoid arthritis. J Clin Med. 2019;8(5):E693.
doi:3390/jcm8050693
11. Tomofuji Y, Kishikawa T, Maeda Y, et al. Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease.
Ann Rheum Dis. 2022;81(2):278-288. doi:1136/annrheumdis-2021-221267